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eLife 8 , e43764 (2019)

Hemoglobin, again, hemoglobin A1C is better

Areas of particular focus included administration of Akkermansia in the body, its impact on IR, the correlated changes in body composition after supplementation, potential improvements in prediabetes or metabolic syndrome, GLP-1 production, and the correlation between Akkermansia and lipid profiles

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From a pragmatic point of view, a successful weight loss drug that doesnt require you to diet and exercise probably isnt great for all the guilt sign ups powering PLNTs ability to make a buck (although I fully support people changing their diet and exercise, there is the question of if they were going to do that they wouldnt have needed the drug in the first place...)

If your lifestyle doesnt allow for frequent appointments, you might not be a good candidate for the medication