what is a glp-1 analogue Comparing Ozempic, Wegovy and Other Drugs GLP-1 receptor agonists | How

Risk of Amputation: There is an increased risk of lower limb amputation (toes, feet) associated with empagliflozin, particularly in patients with prior amputations, peripheral vascular disease, neuropathy, and diabetic foot ulcers

Wegovy 2.4 mg weekly for weight management): Demonstrated 15-17% weight loss in STEP trials and significant cardiovascular benefits in SUSTAIN and SELECT trials Liraglutide (Victoza 1.8 mg daily for diabetes

Safety and Side Effects GLP-1 injections are generally well tolerated

Providers generally initiate one agent first, assess tolerance, then add the second at low dose with regular follow-ups

This will be a central focus of the FDA review

Food and Drug Administration (2023) Jardiance highlights of prescribing information, The U.S