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In the JAMA paper: expression of the GLP-1 receptor in the human optic nerve and GLP-1 RAinduced enhanced sympathetic nervous system activity might influence optic nerve head perfusion. =Rapid lowering of blood glucose (and rapid change in metabolic state) in persons with pre-existing retinopathy may worsen ocular microvascular conditions (though this is more established with insulin rather than semaglutide specifically)

Others require proof of failed attempts with older medications (such as phentermine or orlistat) before approving a GLP-1 receptor agonist, a requirement known as step therapy that can extend delays by weeks

Plasma EV proteomic analysis Human plasma sample Plasma samples were obtained from the study participants at KNUH