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REDEFINE 1 evaluated the combination in adults with overweight or obesity without type 2 diabetes over a 68-week design, comparing the combination against the individual components and placebo [5]

doi: 10.1053/j.jrn.2017.11.007 19 BobotM.ThomasL.MoyonA.FernandezS.McKayN.BalasseL.et al

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Even though some studies have shown that SGLT2 inhibitors modestly increase HDL cholesterol levels compared with placebo, there are also available data suggesting a small increase in LDL cholesterol [26, 29]

15 Mechanistic actions of TPE include removing toxic agents, cytokines, and abnormal inflammatory proteins 20 such as amyloid beta (A) proteins 21

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