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Like other copper-binding tripeptides, its biological effects are proposed to occur through both the peptide backbone and the copper ion it coordinates with the copper contributing to enzymatic cofactor activity and oxidative stress modulation

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Because it activates both, it's often called a "dual agonist." The FDA has described tirzepatide (brand name Zepbound) as the first medication of its kind to activate both of these receptors for weight management, and it was approved for that use in November 2023

The medication works by mimicking the action of two naturally occurring incretin hormones that are released after eating

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Nampt controls skeletal muscle development by maintaining Ca2+ homeostasis and mitochondrial integrity