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Compound A is predicted as non-toxic

AR has been implicated in the etiology of secondary complications of diabetes, and AR inhibitor (ARI) epalrestat has been widely adopted in clinical management of secondary diabetic complications in mainland China [17] and Japan [18]

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Studies have shown that the combination of the proteasome inhibitor carfilzomib and iodine-125 ( 125 I) seed radiation exhibits potent antitumor effects

This framework summarizes what we know about each component and the gap in evidence for combination therapy