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Tirzepatide has demonstrated superior efficacy in both weight loss and blood glucose control compared to semaglutide (Aronne et al., 2025), highlighting the therapeutic potential of multi-agonist strategies

Wang Z, Liu J, Jianjun L, et al

4.2 GLP-1-based agents The focus of GLP-1RA development has predominantly been on designing GLP-1 derivatives resistant to DPP-4 enzymatic activity and exhibiting slow renal clearance through chemical modification and pharmaceutical formulation

Renal Hemodynamic Effect of Sodium-Glucose Cotransporter 2 Inhibition in Patients With Type 1 Diabetes Mellitus

For instance, rodents given GLP-1 drugs drink less alcohol, self-administer less cocaine and show less interest in nicotine

By stimulating all three pathways simultaneously, retatrutide could assist the body in controlling both appetite and metabolism