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Tier 1 (low risk): single CNS agent, no opioid, eGFR above 60, age below 65

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This is the pharmacological reason oral NAC dosing tends to be higher than you might expect from its potency most of what you take is metabolized before it reaches systemic circulation

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The research protocol got approval from the Zagazig University Animal Care and Use Committee (code number ZU-IACUC/3/F/228/2022)