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Kappa opioid receptors (KORs) also regulate DA release through their direct effect on DA neurons and are implicated in aversion including opioid withdrawal [9, 10]

For patients, the practical takeaway is simple

While deficiency may impair skeletal development and mineral metabolism, excessive intake can result in toxicity

doi:10.1016/0006-8993(95)00209-9

Use fresh diluent and maintain strict sterility throughout reconstitution and injection