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Women who initiate HRT before age 60, or within approximately ten years of their final menstrual period, appear to have a substantially more favorable risk profile than those who begin later

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Understanding the precise mechanisms driving the alterations in bioavailability, for instance saturation of efflux transporters and/or saturation of metabolic deactivation, are also important for assessing the toxicological implications of novel formulations

High TMAO in the blood can cause abnormal blood clots and is a good predictor of heart attack and stroke