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& Poulsen, R

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[5961] With increasing attention on the metabolic role of MSTN, a study demonstrated that inhibition of MSTN ameliorated type 1 diabetes in mice by improving insulin sensitivity and enhancing the expression of Glut1 and Glut4 glucose transporters in skeletal muscle.[62] This was found to be the same in humans as elevated circulating MSTN levels have also been found in patients with type 1 diabetes.[63] Collectively, these observations highlight the therapeutic potential of targeting MSTN for the treatment of metabolic disorders, including obesity and diabetes

Burping and other gastrointestinal symptoms are typically most noticeable during the initial titration phase and often diminish over time as the body adapts to the medication

For instance, a study found that semaglutide 1.0 mg once weekly plus basal insulin significantly reduced mean HbA1c (a measure of long-term blood sugar control) compared to insulin when taken over 26 weeks [10]

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