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[16] Reported rates from trials include: Nausea: ~44% Vomiting: ~25% Diarrhea: ~31% Constipation: ~23% Dyspepsia: ~10% These effects reflect slowed gastric motility and are usually mild, but can lead to clinical implications: Dehydration Electrolyte abnormalities ED presentations for poor oral intake

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Potential Side Effects of Slowed Digestion and How to Manage Them Because gastric emptying slows on GLP-1 therapy, some people experience nausea, especially when starting treatment or increasing their dose