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Four literature reviews concluded GLP-1s increased bone formation, three of which found them superior to other diabetes medications

This can be especially problematic around the abdomen

GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure

Additionally, the distribution of weight loss matters

Originally developed as diabetes medications, semaglutide and tirzepatide are often prescribed for weight loss GLP-1 (glucagon-like peptide-1) receptor agonists are medications that mimic the GLP-1 hormone, which helps regulate blood sugar levels and appetite

However, some healthcare professionals and pharmacies may offer compounded versions instead