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This phenomenon is well-documented in weight loss research, regardless of the method used to achieve weight reduction

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NICE guidance (NG49) on NAFLD management emphasises lifestyle modification as the cornerstone of treatment, with weight loss of 710% recommended to achieve histological improvement

But growing demand, high costs and intermittent shortages have fueled a market for compounded and gray-market versions of the drugs online, raising concerns about product quality, dosing and safety

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Nature PubMed Preclinical literature and narrative reviews describe pleiotropic actions including angiogenesis modulation (promotion in healing contexts and proposed inhibition in rodent corneal neovascularization models) and purported cytoprotective effects across diverse injury paradigms, but these remain unconfirmed in controlled human experiments