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Mechanistically, alterations in gut microbial metabolites such as SCFAs could affect the integrity of the BBB, induce systemic endotoxemia, and activate microglia so as to impact disease progression

Diabetes 62:A257A257 Henderson SJ, Konkar A, Hornigold DC et al (2016) Robust anti-obesity and metabolic effects of a dual GLP-1/glucagon receptor peptide agonist in rodents and non-human primates

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Moreover, AC has been shown to inhibit ACE activity in a dose-dependent manner, with an IC50 of 365 M (Oh et al

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In addition to a varied and balanced diet and a healthy lifestyle