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Current guidelines recommend tirzepatide for weight loss in adults who meet one of the following criteria: A Body Mass Index (BMI) of 30 or higher (classified as obesity), or A BMI of 27 or higher with at least one weight-related medical condition, such as high blood pressure, type 2 diabetes, or high cholesterol

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Preclinical data in rodent models showed approximately 37% greater hepatic fat reduction versus tirzepatide-equivalent dosing, a finding cited in multiple human trial design rationales as justification for the Retatrutide vs Tirzepatide superiority hypothesis in hepatic metabolic disease contexts