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Adverse event rates reflect aggregate clinical trial and systematic review data

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This is the ladder documented in the Wegovy prescribing information and mirrored in the STEP trial program

Coskun T, et al

The reasons for these differences may be related to the small sample size and the difference in drug intervention dose

5,8 Recent data from an observational Japanese study of oral semaglutide users found that sleeping more than six hours per night and improving sleep quality during treatment were independently associated with greater odds of achieving at least 3 percent weight loss, whereas severe stress, late-night dinner after 9 pm, and sleeping within three hours of dinner were linked with poorer weight loss outcomes