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Glucagon-like peptide-1 and its class B G protein-coupled receptors: a long march to therapeutic successes

In the LEADER trial, over 9,340 patients with type 2 diabetes and high cardiovascular disease risk underwent randomization to liraglutide or placebo and were followed for a median of 3.8 years resulting in a 13% risk reduction in a combined endpoint of death from cardiovascular cause, nonfatal myocardial infarction, or nonfatal stroke [46]

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Keep the vial upright and away from light

General discussion The principles of pharmacotherapy for patients with T2D have been thoroughly reviewed by Diabetes Canada

These cardiovascular benefits likely require sustained, adequate receptor activation across all three targets, raising further questions about whether microdosing preserves them