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In addition, plasma TMAO levels have been reported to gradually increase with age, and this process is regulated by changes in diet and an increase in abundance of TMA-producing bacteria (60)

When intracellular iron accumulation and the redox system become imbalanced, excessive production of lipid peroxides will occur, ultimately inducing ferroptosis

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Biol Trace Elem Res 143:17581776 Hasanuzzaman M, Fujita M (2013) Exogenous sodium nitroprusside alleviates arsenic-induced oxidative stress in wheat ( Triticum aestivum L.) seedlings by enhancing antioxidant defense and glyoxalase system

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