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The IGF-1 receptor consists of two alpha subunits and two beta subunits linked by disulfide bonds, forming a heterotetrameric structure

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illustrated that neuronal precursor cell-expressed developmentally downregulated 4 (Nedd4), is capable of ubiquitylating as well as degrading VDAC2/3, thereby modulating ferroptotic processes in melanoma cells triggered by erastin specifically (Yang et al., 2020)