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It should not be presented as a topical substitute for fillers, fat transfer, or other procedures intended to restore facial volume

However, narrative reviews were excluded from this scoping review

Symptoms requiring routine medical review: Bloating that persists beyond 46 weeks despite dietary modifications and adequate dose titration Symptoms that significantly impact quality of life or ability to maintain adequate nutrition New or worsening heartburn or regurgitation, which may indicate gastro-oesophageal reflux disease (GORD) Changes in bowel habit such as persistent diarrhoea or constipation Concerns about medication adherence due to gastrointestinal side effects Your healthcare professional may recommend investigations to exclude other causes of bloating, particularly if symptoms are atypical or severe

A 2015 lawsuit alleging the company was a pyramid scheme was eventually dismissed

The Insulin Response to Oral Glucose in GIP and GLP-1 Receptor Knockout Mice: Review of the Literature and Stepwise Glucose Dose Response Studies in Female Mice

The research is clear