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Its local pharmacological characteristics provide a new idea for the treatment of obesity.AOD 9604, as an anti-obesity polypeptide targeting subcutaneous adipose tissue, achieves the effect of local fat reduction by activating lipolysis and inhibiting fat production

A recent study suggests that Bcl-2 regulates mitochondrial GSH content by a direct interaction of the BH3 groove with GSH [132], while the antiapoptotic effect of Bcl-xl has also been attributed to the regulation of GSH homeostasis by preventing GSH loss [133] Figure 5

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Semaglutide fundamentally alters the gastrointestinal environment

In doing so, it also reduces appetite and promotes a feeling of fullness, which is why these medications have become central to both diabetes management and weight loss treatment