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J Clin Invest (2020) 130:1491505

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3 Cardiovascular effects of GLP-1 receptor agonists: clinical evidence beyond glycemic control Since the FDA mandate in 2008 to demonstrate cardiovascular safety for new glucose-lowering agents, a series of large randomized cardiovascular outcome trials have evaluated GLP-1 RAs in patients with T2DM, many of whom had established atherosclerotic cardiovascular disease (ASCVD) or multiple risk factors

The clinical evidence consistently shows that tirzepatide produces greater weight loss than semaglutide, and for patients who need to lose 20% or more of their body weight to reach a healthy range, that additional efficacy can be clinically meaningful