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It also provides the clinical foundation for asking whether adding glucagon receptor activation can further increase efficacy

doi: 10.1007/s11306-019-1625-z 70 AletahaDNeogiTSilmanAJFunovitsJFelsonDTBinghamCOet al

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Some patients report improved mental sharpness, consistent with IGF-1's established role in neurological function and brain metabolism.[6] These benefits do not happen in isolation