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Diet-induced obesity models animal-model research has explored AOD-9604's effect on body composition, fat-mass markers, and energy expenditure in rodent obesity models

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Its primary function is transporting fatty acids into mitochondria, the cell's power plants, for energy production

Then, tissue samples were chopped with scissors in digestion buffer (HBSS supplemented with Ca and Mg and 0.5% FFA-BSA), transferred to a conical tube and mixed (10:1 v/v) with collagenase solution (10 mg/mL Collagenase Type II) and incubated at 37 C in a water bath for 2045 min with orbital shaking until the digestion was completed

doi:10.1681/ASN.2015020190 9

Hamaguchi E, Takamura T, Sakurai M, et al