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Furin cleavage of PA results in its oligomerization at the cell surface into a pre-pore that facilitates membrane interactions with edema factor and lethal factor
meanwhile, in the adrenal cortex, Ang II stimulated the secretion of aldosterone, thereby increasing the absorption of water and sodium in collecting duct principal cells (120)
Repeated cortisone injections actually weaken tendon tissue over time, trading short-term relief for long-term structural vulnerability
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Heavier application shortens that window