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This process happens in two phases

HSP90 directly interacts with GPX4, inhibiting GPX4 activity and resulting in ferroptosis [112]

Tnfrsf1b is involved in regeneration and tissue repair and its down-regulation has been shown to increase apoptosis of sperm cells

At the signaling level, AMPK antagonizes mTORC1, a central node controlling the glycolysisoxidative metabolism balance

Cells were allowed to attach overnight before the addition of compounds solubilized in dimethylsulfoximide (DMSO) and diluted in complete culture medium with a fixed final DMSO concentration of 0.5%

Despite essential role of GluK3 receptors at the presynaptic sites in the hippocampal mossy fibre synapse 10 , it is one of the least studied KA subunits with respect to structure-function analysis