These two agents work through different mechanisms to support weight loss, offering a complementary approach
ACSL4 acyl-CoA synthetase long-chain family member 4
While additional research is needed to determine how GLP-1 RAs put a person at an increased risk for NAION, it may be linked to fluctuations in blood pressure and blood sugar, diabetes-related vascular issues, and low blood sugar (hypoglycemia) caused by Mounjaro
Consistent with this finding, postmortem studies have reported markedly downregulated gene expression of antioxidant enzymes such as SOD1 and glutathione S-transferase in the hippocampus of BD patients, a finding that may relate to bipolar depression as the dominant phase [56]
The plan could expose division between CMS head Mehmet Oz, who has previously praised such drugs, and health secretary Robert F Kennedy Jr, who has criticized their high cost and how they are not a substitute for a healthy lifestyle.
10.1186/s12935-023-03108-0 8 BaralleF