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GLP-1 medications treat diabetes by mimicking GLP-1 to signal to the body to release glucose-dependent insulin from the pancreas and slows the speed of stomach emptying, extending the feeling of a full stomach and curbing the appetite

Common adverse effects of GLP-1 medications include gastrointestinal symptoms such as nausea, vomiting, diarrhoea, and constipation, particularly during dose escalation

N Engl J Med 375:311322 Holman RR, Bethel MA, Mentz RJ et al (2017) SUSTAIN-6 Investigators Effects of once-weekly exenatide on cardiovascular outcomes in type 2 diabetes

Ryaby JT, Sheller MR, Levine BP, Bramlet DG, Ladd AL, Carney DH

Guo, Z., Si, T., Yang, X