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Viruses alter redox balance within infected cells leading to inflammation and tissue damage

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The cytotoxicity of Ru(II)-OH, NP2, and NP4 against 143B and K7M2 cells in a 21% O 2 or 1% O 2 atmosphere was studied using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay

Once oxidised, glutathione penetration is more challenging and also oxidised glutathione has less efficacy as compared to the reduced glutathione