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One great way to do so is by drinking plenty of water and eating a diet rich in fruits and vegetables both excellent detoxifiers

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Methods and results are included in Supplementary data

It is reported that high concentrations of fumarate and succinate can enhance the 3-methylation of histones H3K4 and H3K27 by inhibiting KDM5 histone demethylase (responsible for H3K4 demethylation) and JMJD3 histone demethylase, respectively, which in turn promotes the expression of pro-inflammatory cytokine genes (99, 115, 125, 161, 162)

Whether this decline is a cause or consequence of aging and disease remains an active area of research