While the study establishes a compelling systemic role for SLC25A45 in fuel switching, important questions remain regarding the tissue-specific contributions of this pathway and how carnitine biosynthesis and utilization are differentially regulated across dietary, disease, and sexually dimorphic contexts
I believe this is going to be a very fruitful find, says Birsoy
Dialysis duration ranged from 2 h to 19 days
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Synaptic function A growing number of genes that have been associated with ASD seem to play roles in synaptic structure and function by directly encoding synaptic scaffold proteins, neurotransmitter receptors, cell adhesion molecules, and actin cytoskeletal dynamics-related proteins (Fig