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Genetic Factors in GLP-1 Tolerance and Digestive Side Effects Individual variations in how your body processes and responds to GLP-1 medications are partly determined by your genetic makeup, particularly genes controlling GLP-1 receptor function, appetite signaling, and gastrointestinal motility

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Pleasure This mental conflation between eating for biological satiety (meeting your bodys actual needs) and pleasure (the dopamine surge from consuming tasty food) is at the heart of how GLP-1s seem to quiet the storm