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In the United States alone, the annual direct medical costs associated with RA are estimated to exceed $19 billion, with indirect costs such as lost productivity further amplifying the economic impact 5

Our previous findings indicated that exposure to SPT significantly reduces the number and diameter of fetal muscle fibers (Turgut et al., 2025a), potentially impairing postnatal growth and development (Turgut et al., 2025b)

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This reduction in growth hormone levels correlates with numerous age-related manifestations including weight accumulation, fatigue, and diminished muscle mass

Carriche et al., 2021)