Additionally, 43.2% of patients on the high dose reported nausea and 33.1% reported diarrhea, compared with 10.7% and 13.4% in the placebo group
That was a turn-off for both patients and insurers
Amongst other GLP-1R agonists, Exenatide uses a combination of mechanisms which may include glucose-dependent stimulation of insulin secretion, suppression of glucagon secretion, enhancement of -cell mass, slowing of gastric emptying, inhibition of food intake, and modulation of glucose trafficking in peripheral tissues (Nielsen, 2004)
Phase 3, Randomized, Double-Blind, Active-Comparator (Darbepoetin Alfa) Study of Oral Roxadustat in CKD Patients with Anemia on Hemodialysis in Japan
In case of diarrhea, stay hydrated and consult your doctor for over-the-counter medication
According to NICE guidelines, maintaining good glycaemic control is essential for reducing the risk of both microvascular and macrovascular complications