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Accessed June 10, 2021

doi: 10.1016/j.diabet.2012.08.011 10 ChenGTanCLiuXWangXTanQChenY

Medicine, 102(52), e36730

Tumor growth experiments conducted in syngeneic mice inoculated with MC38 cells using PD-1 immune checkpoint inhibitors demonstrated that while BEBT-908 (a dual HDAC/PI3K inhibitor) alone could delay the growth of MC38 tumors, its efficacy was significantly enhanced when combined with anti-PD-1 antibodies, with some host mice surviving for extended periods

Animals with obesity experience a decrease in the excitability of vagal afferent neurons, leading to reduced activation in response to hormonal metabolic signals from the gut [36]

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