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Mitchell JD, Wokke JH, Borasio GD: Recombinant human insulin-like growth factor I (rhIGF-I) for amyotrophic lateral sclerosis/motor neuron disease

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and global patients illustrates the significant runway that remains for obesity treatments and the companies developing them

Colloff et al., 1992

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The part that doesnt get enough airtime is the operational complexity this introduces: - Dose reproducibility at micro volumes - Device variability and aging behavior - Extractables / adsorption risks - Cleaning, sterility, and cross-contamination strategy - Human factors becoming part of product performance At that point, youre no longer optimizing a molecule