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Labeling and instructions can differ from the approved product, which makes dose comparisons less straightforward

The nausea profile differs between the two medications

For tissue imaging, matrix performance impacts four key aspects of MALDI-MSI: efficient analyte extraction (poor extraction reduces sensitivity), small crystal size (critical for high spatial resolution), high purity (minimizes background ion interference), and uniform crystal layer formation (ensures reproducibility and enables for quantitative analysis)

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Inflammatory bowel disease (IBD) patients, including those with Crohn's disease or ulcerative colitis, require careful evaluation before GLP-1 use