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Strikingly, GGCT-mutant cells effectively counteracted this metabolic augmentation, rescuing the levels of key intermediates including pyruvate, succinate, and fumarate (Fig

& Brini, F

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162 These inflammatory cytokines reduce the expression of NAMPT

Achieving site-specific transcranial drug delivery to closed-skull TBI patients may be more difficult than the authors imply: the subarachnoid space filled with circulating cerebrospinal fluid (CSF) is about 3-4 mm deep in humans (3), more than an order of magnitude deeper than in mice, permitting CSF to quickly remove drug molecules from a targeted cortical site