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In colorectal cancer cells with mutant KRAS, SLC25A22-mediated glutaminolysis reduces DNA demethylation to increase WNT signaling, stemness, and drug resistance

Notably, the effect of tirzepatide as an anti-obesity medication is being investigated in the ongoing SURMOUNT clinical trial programme, in a similar manner to the assessment of semaglutide 2.4 mg for obesity in the Semaglutide Treatment Effect in People with obesity (STEP) programme [27]

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