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Endoscopic, surgical and other therapies A number of invasive therapies have been used in individuals with refractory diabetic gastroparesis, but none can currently be considered to have an established place in management

The long-term weight loss effect of GLP-1RAs has also been validated in a recent large-scale clinical trial, which reported a weight loss up to 20.9% after 72-week treatment of tirzepatide [22]

One important factor may be that effect sizes are much smaller than expected based on the initial positive findings, because of a bias towards publishing positive but not negative, results [238]

It should always be monitored by a healthcare provider

DSIP's theoretical advantage (minimal next-day sedation and potential physiological sleep architecture improvement) has not been confirmed in modern trials