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Another significant nutritional aspect of durian pulp is its outstanding antioxidant properties, which are primarily attributed to its high polyphenol content 26

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and caveolin-1 (CAV1), a scaffold protein of caveolar membranes involved in signal transduction and in the uptake of lipophilic compounds, which directly interacts with NRF2, probably competing with KEAP1 for binding to NRF2, and subsequently suppresses its transcriptional activity [231]