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For weight management, treatment duration may depend on achievement and maintenance of weight loss goals, with some patients requiring long-term therapy to maintain weight reduction while others may successfully transition to lifestyle modifications alone after achieving target weight

These reductions represented estimated treatment differences ranging from 3.0% to 7.8% weight loss versus placebo, all of which were statistically significant

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Possible poor response to treatment Sometimes, hydroxocobalamin might not work as well if you have other health problems, such as infection, uremia (buildup of urea in the blood), or low iron or folic acid levels

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A more complete result can take 3 to 6 months of consistent use