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5 While injectable medications like Wegovy and Zepbound often achieve 15-20% weight loss 6,7 , the results of this trial are still clinically meaningful as a 10-15% reduction of body weight provides significant metabolic benefits

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Clinicians should assess GLP-1 candidates for sleep quality, patterns, and duration using validated questionnaires like STOP-BANG [177], sleep initiation, sleep maintenance, or hypnotic drug use to assess insomnia [178] or questions about restless legs syndrome [179]

1c, 3c, d and Supplementary Figs

These factors make stretching, dimpling, and uneven texture more common in these areas compared to others