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Independent HPLC analysis of peptide degradation curves shows that GHK-Cu stored at 1015C loses approximately 1218% potency within the first week

It has a different side effect and risk profile than SGLT2 inhibitors and has been used off-label for weight loss

Patients should not attempt to stop either medication abruptly without medical guidance, as phentermine cessation can cause fatigue and mood changes, while sudden semaglutide discontinuation may trigger rebound appetite and rapid weight regain

Long-Term Outcomes Semaglutide may produce immediate effects on weight loss, but sustained results are typically observed over the long term with consistent treatment adherence

doi: 10.1083/jcb.200210169

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