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The reasons cited by the FDA included concerns about immunogenicity, peptide impurity characterization challenges, and the lack of adequate safety data from human clinical trials

reported that Exos derived from adipose-derived stem cells (ADSC-Exos) deliver Fxr2, which stabilizes Atf3 mRNA in M2 microglia, therapy inhibiting ferroptosis, reducing inflammation and promoting neuronal survival [138]

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