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In 2015, a review and meta-analysis of eight studies, including 910 women with PCOS, found that NAC increased ovulation (four trials), pregnancy (three trials) and live birth (one trial) rate by more than three times compared with placebo

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Gastrointestinal adverse events increased across treatments, discontinuation was highest with semaglutide 7.2 mg, and serious adverse events were comparable to placebo

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This makes it uniquely suited for oral bioavailability research

Therefore, more in vivo and in vitro experiments are still needed (Figure 1)