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Alpha-KGDH is vital for maintaining NADH supply to the respiratory chain and is limited only when alpha-KGDH is also inhibited by ROS

Unfortunately, many of these claims are not backed by clinical evidence

The FASEB Journal , 29

When the gut lining is inflamed and permeable, neurotransmitter production is disrupted, inflammatory cytokines cross into systemic circulation and reach the brain, and the vagus nerve the primary communication cable between gut and brain transmits distress signals that manifest as anxiety, brain fog, and fatigue

doi: 10.1016/j.phrs.2012.11.005 59 DavisD