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NADH electrons can be efficiently utilized to reduce oxaloacetate (OAA) to malate via cytosolic malate dehydrogenase (encoded by the MDH1 gene)

103 However, Wnt3a is reported to be capable of activating transcriptional coactivator with PDZ-binding motif (TAZ), which can directly upregulate IRS-1, indicating its potential ability of increasing insulin sensitivity in muscle

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