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In addition, in human alveolar epithelial cell, GHK-Cu significantly enhanced the expression of HO-1 which has been reduced by the stimulation of CSE

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In addition to functioning as a purification tag, GST acts as a chaperone for the attached protein, promoting its correct folding, as well as preventing it from becoming aggregated in inclusion bodies when expressed in bacteria

Ethics declarations Ethics approval and consent to participate All animal experiments were approved by the Animal Ethics Committee of Shanghai Jiao Tong University (A2023125-001) and conducted in accordance with the NIH guidelines for animal ethics